Targos News

The One Health Initiative: Comparative Pathology

Comparative pathology: The “One Health initiative” www.onehealthinitiative.com fosters close interactions between physicians and veterinarians with the goal to further investigate neoplastic, nutritional and metabolic diseases, environmental health threats and zoonotic diseases.  First, the initiative will help to identify animal models for certain human diseases, second, it will show whether prognostic factors and treatment options for certain human diseases are suitable for those diseases in animal species as well.

Due to increasing interest in this area, Targos now offers services in this field of pathology upon request. The Targos on site pathology group features solid expertise in veterinary pathology, since PD Dr. Sandra Schöninger (1,2) joined the team from University Leipzig. 

Laboratory animal pathology: The early involvement of a veterinary pathologist in laboratory animal research will likely improve research data, since it allows to distinguish species-specific features and background findings from research-related tissue alterations [link continuous education].

Diagnostic pathology: The pathological work-up of resection specimens and biopsies has diagnostic, prognostic and therapeutic relevance. Provided diagnostic expertise involves the microscopic examination of degenerative, infectious and neoplastic diseases of different animal species including dogs, cats, horses, bovine, sheep and others.

 

Niere einer gealterten Ratte mit chronisch fortschreitender Nephropathie

Kidney of an aged rat with chronic progressive nephropathy. The disease is characterized by interstitial fibrosis (asterisks) and infiltration with mononuclear cells (hash character), the presence of markedly dilated tubules with intraluminal protein casts (arrowheads) as well as glomeruli with thickened basement membranes (arrows). Chronic progressive nephropathy is a common background lesion of rats aged more than 1 year. Bar = 200µm

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Kidney of a dog with antifreeze intoxication

Kidney of a dog with “antifreeze” intoxication. The cause is ingestion of ethylene glycol, that has a sweat taste. Intoxications of dogs and cats are mainly caused by the oral uptake of spilled engine antifreeze solutions. Intoxication leads to formation of calcium oxalate crystals in kidneys that are mainly located in tubular lumens (arrows) and may cause renal failure. Bar = 100µm.

Please contact Targos for more information!

  1. Digital microscopy – Is there a need for standardization?, Schöniger S., Bänfer G., Dietzko R., Jasani B., Virchows Archiv, 2019 (475 Suppl. 1)
  2. A review on mammary tumors in rabbits: translation of pathology into medical care, Schöniger S., Degner S., Jasani B., Schoon H.-A., Animals (Basel), 2019: 9(10). pii: E762.
  3. Expression of indoleamine 2, 3-dioxygenase 1 as transcript and protein in the healthy and diseased equine endometrium, Schöniger S., Gräfe H., Schoon H.-A., Research in Veterinary Science, 2018:(118) 278-287